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Participants in the first cohort, weighing at least 88 pounds, will receive 300 milligrams (mg) of nirmatrelvir and 100 mg of ritonavir by mouth twice a day for five days. This is the same dosage. As shown in table 1, 31 patients with SRD received nirmatrelvir/ritonavir (n=29) or molnupilavir (n=2) (but no other treatment) during the first 5 days after COVID-19 diagnosis by their rheumatologist according to national guidelines.The majority (29/31, 94%) were fully vaccinated (three doses: 80.6%, four doses: 12.9%) against SARS-CoV-2 with mRNA vaccines and were on treatment with bDMARDs.
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